PG-005, a selective inhibitor of BMP7, is a novel functional cyclic peptide capable of selectively inhibiting the signaling of the BMP7 family (BMP5, BMP6, BMP7). Together with PG-006, a BMP4 selective inhibitor, PG-005 and PG-006 enable the selective inhibition of BMP4 and BMP7 signaling, which was not possible with existing small kinase inhibitors or Noggin.

This peptide can be utilized for detailed analysis and control of BMP signaling, as well as for the construction of new cellular differentiation pathways. The molecular weight of PG-005 is 2085.29 (acetate), and it exhibits comparable inhibitory activity against the BMP7 family to Noggin on a molar basis.